Acyclovir Mechanism Of Action
It has antiviral activity against herpes virus. Acyclovir has activity against herpesviruses.
Pharmacology and mechanism of action.
Acyclovir mechanism of action. Take acyclovir for the entire length of time prescribed by. The drug may be administered topically to the skin intravenously orally or topically to the eye only topical and intravenous preparations are currently. Sitavig acyclovir tablet delayed release is only for use in treating cold sores on the lips.
Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old. Acyclovir is a synthetic purine analogue acyclic nucleoside analogue. Other uses include prevention of cytomegalovirus infections following transplant and severe complications of epstein barr virus infection.
Acyclovir is a nucleotide analog antiviral used to treat herpes simplex varicella zoster herpes zoster herpes labialis and acute herpetic keratitis l7303 l7315 l7318 l7321 l7324 l7327. Acyclovir is a new antiviral drug that acts as a specific inhibitor of herpesvirus dna polymerase. Acyclovir is an acyclic analogue of 2 deoxyguanosine.
Acyclovir is a herpes simplex virus nucleoside analog dna polymerase inhibitor and herpes zoster virus nucleoside analog dna polymerase inhibitor and herpesvirus nucleoside analog dna polymerase inhibitor. It shows good in vitro activity against herpes simplex and varicella zoster viruses. The mechanism of action of acyclovir is as a dna polymerase inhibitor.
The action is related to the affinity for the enzyme thymidine kinase tk. The chemical classification of acyclovir is nucleoside analog. The drug may be administered topically to the skin intravenously orally or topically to the eye only topical and.
Acyclovir is used to treat infections caused by herpes viruses such as genital herpes cold sores shingles and chickenpox. Acyclovir 9 2 hydroxymethyl guanine is a nucleoside analog that selectively inhibits the replication of herpes simplex virus types 1 and 2 hsv 1 hsv 2 and varicella zoster virus vzv. Acyclovir is converted to its triphosphate form acyclovir triphosphate acv tp which competitively inhibits viral dna polymerase incorporates into and terminates the.
It can be taken by mouth applied as a cream or injected. Aciclovir acv also known as acyclovir is an antiviral medication. Sitavig will not treat genital herpes.
It is primarily used for the treatment of herpes simplex virus infections chickenpox and shingles. It shows good in vitro activity against herpes simplex and varicella zoster viruses. However resistance among some virus forms is possible because of changes in tk or in the dna.
Acyclovir was granted fda approval on 29 march 1982. Acyclovir is a new antiviral drug that acts as a specific inhibitor of herpesvirus dna polymerase. After intracellular uptake it is converted to acyclovir monophosphate by virally encoded thymidine kinase.
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